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Notch signaling in CD66+ cells drives the progression of human cervical cancers

ABSTRACT: Microarry based whole genome expression analysis was done for the more tumorigenic CaSki spheroids cultures and the less tumorigenic CaSki adherent cultures to identify signaling mechanisms that vary between the two populations. Subsequent to this, an independent array was done to characterize the differences in gene expression between the Lin-CD66+ and the Lin- CD66- cells isolated from primary human cervical carcinomas. The second array was custom-designed and had genes implicated in stemness, epithelial differentiation, signaling pathways implicated in stemness (Notch and Wnt) and cell cylce-regulation. Refer to individual Series. This SuperSeries is composed of the following subset Series: GSE26417: Microarray analysis of CaSki cell line grown as spheroids and adherent conditions GSE26418: Microarray analysis of Lin- CD66+ and Lin- CD66- cells isolated from primary human cervical cancer

ORGANISM(S): Homo sapiens

SUBMITTER: Sudhir Krishna

PROVIDER: E-GEOD-26419 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Microarray analysis of Lin- CD66+ and Lin- CD66- cells isolated from primary human cervical cancer

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Microarray analysis of Lin- CD66+ and Lin- CD66- cells isolated from primary human cervical cancer

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Microarray analysis of CaSki cell line grown as spheroids and adherent conditions

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Notch signaling in CD66+ cells drives the progression of human cervical cancers

Project description:Microarry based whole genome expression analysis was done for the more tumorigenic CaSki spheroids cultures and the less tumorigenic CaSki adherent cultures to identify signaling mechanisms that vary between the two populations. Subsequent to this, an independent array was done to characterize the differences in gene expression between the Lin-CD66+ and the Lin- CD66- cells isolated from primary human cervical carcinomas. The second array was custom-designed and had genes implicated in stemness, epithelial differentiation, signaling pathways implicated in stemness (Notch and Wnt) and cell cylce-regulation. This SuperSeries is composed of the SubSeries listed below.

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