Unknown,Transcriptomics,Genomics,Proteomics

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Genome-scale reconstruction of the PurR regulon reveals its role in the adenine stimulon of Escherichia coli K-12 MG1655


ABSTRACT: This SuperSeries is composed of the following subset Series: GSE26588: Transcriptome analysis of E. coli MG1655 GSE26589: ChIP-chip of E. coli K-12 MG1655 with antibody against PurR-8myc under various conditions. Refer to individual Series

ORGANISM(S): Escherichia coli str. K-12 substr. MG1655

SUBMITTER: Bernhard Palsson 

PROVIDER: E-GEOD-26591 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

The PurR regulon in Escherichia coli K-12 MG1655.

Cho Byung-Kwan BK   Federowicz Stephen A SA   Embree Mallory M   Park Young-Seoub YS   Kim Donghyuk D   Palsson Bernhard Ø BØ  

Nucleic acids research 20110513 15


The PurR transcription factor plays a critical role in transcriptional regulation of purine metabolism in enterobacteria. Here, we elucidate the role of PurR under exogenous adenine stimulation at the genome-scale using high-resolution chromatin immunoprecipitation (ChIP)-chip and gene expression data obtained under in vivo conditions. Analysis of microarray data revealed that adenine stimulation led to changes in transcript level of about 10% of Escherichia coli genes, including the purine bios  ...[more]

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