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Transcription profiling of human lymph node (sinuses) and tonsil (no sinuses) to identify signature genes that are prime candidates for mediating adhesion of tumor cells to sinusoidal cells

ABSTRACT: Lymph node vs. tonsil

ORGANISM(S): Homo sapiens

SUBMITTER: Alexei Gratchev

PROVIDER: E-GEOD-2665 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Differential expression of a gene signature for scavenger/lectin receptors by endothelial cells and macrophages in human lymph node sinuses, the primary sites of regional metastasis.

Martens J-H JH Kzhyshkowska J J Falkowski-Hansen M M Schledzewski K K Gratchev A A Mansmann U U Schmuttermaier C C Dippel E E Koenen W W Riedel F F Sankala M M Tryggvason K K Kobzik L L Moldenhauer G G Arnold B B Goerdt S S

The Journal of pathology 20060301 4

Sentinel lymph node biopsy for several cancers has shown that metastatic tumour cells are preferentially arrested in the lymph node sinuses. To study the molecular components of this sinusoidal trap, gene profiling of lymph node (sinuses) versus tonsil (no sinuses) was performed. Among other groups of molecules, an intriguing gene signature of scavenger and lectin-like receptors was identified. Nine of the 13 genes were preferentially expressed in sinusoidal cells by immunohistochemistry. Using ...[more]

PMID: 16440291

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