Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

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MMRC expression and aCGH reference collection

ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Homo sapiens

SUBMITTER: Michael Chapman 

PROVIDER: E-GEOD-26863 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Initial genome sequencing and analysis of multiple myeloma.

Chapman Michael A MA   Lawrence Michael S MS   Keats Jonathan J JJ   Cibulskis Kristian K   Sougnez Carrie C   Schinzel Anna C AC   Harview Christina L CL   Brunet Jean-Philippe JP   Ahmann Gregory J GJ   Adli Mazhar M   Anderson Kenneth C KC   Ardlie Kristin G KG   Auclair Daniel D   Baker Angela A   Bergsagel P Leif PL   Bernstein Bradley E BE   Drier Yotam Y   Fonseca Rafael R   Gabriel Stacey B SB   Hofmeister Craig C CC   Jagannath Sundar S   Jakubowiak Andrzej J AJ   Krishnan Amrita A   Levy Joan J   Liefeld Ted T   Lonial Sagar S   Mahan Scott S   Mfuko Bunmi B   Monti Stefano S   Perkins Louise M LM   Onofrio Robb R   Pugh Trevor J TJ   Rajkumar S Vincent SV   Ramos Alex H AH   Siegel David S DS   Sivachenko Andrey A   Stewart A Keith AK   Trudel Suzanne S   Vij Ravi R   Voet Douglas D   Winckler Wendy W   Zimmerman Todd T   Carpten John J   Trent Jeff J   Hahn William C WC   Garraway Levi A LA   Meyerson Matthew M   Lander Eric S ES   Getz Gad G   Golub Todd R TR  

Nature 20110301 7339

Multiple myeloma is an incurable malignancy of plasma cells, and its pathogenesis is poorly understood. Here we report the massively parallel sequencing of 38 tumour genomes and their comparison to matched normal DNAs. Several new and unexpected oncogenic mechanisms were suggested by the pattern of somatic mutation across the data set. These include the mutation of genes involved in protein translation (seen in nearly half of the patients), genes involved in histone methylation, and genes involv  ...[more]

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