Browse
Submit Data
Databases
API
Help

Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

TGF-beta treated Schistosoma mansoni

ABSTRACT: Transcriptional profiling of TGF-beta treated Schistosoma mansoni adult worms vs. Non-treated Schistosoma mansoni adult worms Two conditions (treated vs. Non-treated) with three biological samples of treated worms (TGF1, 4 and 5) and two biological samples of non-treated worms that were pooled into a single sample (pool). For each sample (three treated or polled non-treated) were performed four technical replicas

ORGANISM(S): Schistosoma mansoni

SUBMITTER: Katia Oliveira

PROVIDER: E-GEOD-27050 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

ACCESS DATA

Json Xml

Similar Datasets

Effect of Curcumin on expression profile of Schistosoma mansoni adult worms

Project description:Transcriptional profiling of Curcumin treated S. mansoni adult worms (15uM of Curcumin in DMSO during 24h) vs. Non-treated S.mansoni adult worms (DMSO during 24h) Two conditions (treated vs. Non-treated) with four biological samples of treated worms (Curcumin 1, 2, 3 and 4) and four biological samples of non-treated worms (Control 1, 2, 3 and 4). For each sample (four treated and four non-treated) were performed two technical replicas.

2012-12-30 | E-GEOD-37647 | biostudies-arrayexpress

Transcriptome analysis of inhibitor-treated schistosome female

Project description:Transcriptional profiling of S. mansoni adult females treated with Herbimycin A (4.5 ÂµM ) or TGF beta receptor type I kinase inhibitor (TRIKI, 300 nM) or a combined treatment with both inhibitors (Herbimycin A 4.5ÂµM and TRIKI 300nM) vs. Non-treated S.mansoni adult females (DMSO during 48h) Two conditions (treated vs. Non-treated) with three biological samples of treated worms (Herbimycin, TRIKI or Herb+TRIKI) and in parallel other three biological samples of non-treated worms (DMSO) for each treatment condition. For each sample (three treated and three non-treated for each inhibitor combination) were performed two technical replicas.

2013-05-30 | E-GEOD-39732 | biostudies-arrayexpress

Imatinib treatment causes substantial transcriptional changes in adult Schistosoma mansoni in vitro exhibiting pleiotropic effects

Project description:Transcriptional profiling of Imatinib-treated paired adult S. mansoni vs. Non-treated (control) paired adult S. mansoni during 24 and 48 hours Two conditions (Imatinib-treated vs. Non-treated ) for each time of treatment (24 hours and 48 hours) with three biological samples of each conditions. For each biological sample (three Imatinib-treated and three Non-treated for each time of treatment) were performed two technical replicas.

2014-06-20 | E-GEOD-53154 | biostudies-arrayexpress

TGF-beta treated Schistosoma mansoni

Project description:Transcriptional profiling of TGF-beta treated Schistosoma mansoni adult worms vs. Non-treated Schistosoma mansoni adult worms

2012-02-20 | GSE27050 | GEO

Transcription profiling of Schistosoma mansoni adult male and female worms isolated from mice 7-weeks post-infection

Project description:Adult male and female Schistosoma mansoni worms were isolated from mice 7-weeks post-infection. Male material (Cy5) and female material (Cy3) were compared in a direct bimodal comparison. Five independent biological batches were used. Addtional dye-swap experiments male (Cy3) and female (Cy5) were performed using pooled samples of total RNA.

2005-02-01 | E-MEXP-223 | biostudies-arrayexpress

Transcription profiling of Bi-sex male and female Schistosoma mansoni worms isolated from mice 7-weeks post-infection

Project description:Bi-sex male and female Schistosoma mansoni worms were isolated from mice 7-weeks post-infection. Bi-sex male material or female material was compared in a direct bimodal comparison to single-sex male or female material. Two independent biological batches of both bi- and single-sex males were used. One batch of single-sex female material was used in comparisons to three independent biological batches of bi-sex female material. A dye-swap hybridization was performed for each bimodal comparisons in turn.

2006-11-01 | E-MEXP-474 | biostudies-arrayexpress

Project description:ATAC-seq on drug treated Schistosoma mansoni adult worms

| PRJNA830864 | ENA

Comparative proteome analysis of the tegument of male and female adult Schistosoma mansoni

Project description:We present a comparative analysis of sex-specific tegument proteins of paired or virgin Schistosoma mansoni. By apply a new and highly sensitive workflow, detection of even low abundance proteins from the worm was achieved Therefore, a streptavidin-biotin affinity purification technique in combination with single pot solid-phase enhanced sample preparation was established for subsequent LC-MS/MS analysis. We were able to identify 1519 tegument proteins for male and female as to virgin and paired worms. Sex-specific proteins were screened, present in both virgin and paired adult schistosomes to reduce the impact of mating. Bioinformatic analysis revealed an involvement of female-specific tegument proteins in signaling pathways of cellular processes and antioxidant mechanisms. Male-specific proteins were found to be enriched in processes linked to phosphorylation and signal transduction. This suggests a task sharing between the sexes that might be necessary for survival in the host. Our datasets provide a basis for further studies to understand and ultimately decipher the strategies of the two worm sexes to evade the immune system.

2022-05-20 | PXD031167 | Pride

Schistosoma mansoni developmental stages

Project description:Transcriptional profiling using two subsequent developmental stages of Schistosoma mansoni (Egg vs. Miracidium; Cercaria vs. 7-days-old Schistosomulum; 7-days-old Schistosomulum vs. Adult worms

2011-04-30 | GSE27026 | GEO

Combinatory microarray and SuperSAGE analyses identify pairing-dependently transcribed genes in Schistosoma mansoni males, including follistatin [SuperSAGE]

Project description:Comparing the transcriptomes of pairing-experienced (EM) and pairing-unexperienced (UM) male Schistosoma mansoni (in biological triplicates) we detected 253 genes to be significantly differeantially (p < 1-10; log2ratios < -0.585 or > +0.585) transcribed. pairing-experienced (EM) and pairing-unexperienced (UM) male Schistosoma mansoni were compared by SuperSAGE (Matsumura et al., 2003; with minor changes: Molina et al., 2008), sequencing Illumina (Solexa)

2013-09-09 | E-GEOD-45628 | biostudies-arrayexpress

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data