Unknown,Transcriptomics,Genomics,Proteomics

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Drosophila dKDM5/LID regulates H3K4me3 dynamics at the transcription start site of actively transcribed developmental genes

ABSTRACT: This SuperSeries is composed of the following subset Series: GSE26895: Drosophila LID RNAi gene expression profiling GSE27078: LID ChIP-Seq in wild type, and H3K4me3 ChIP-Seq in wild type and lid RNAi Drosophila melanogaster GSE40599: POLIISER5 and POLIISER2 ChIP-Seq in mutant RNAi LID Drosophila Melanogaster Refer to individual Series

ORGANISM(S): Drosophila melanogaster

SUBMITTER: David Rossell 

PROVIDER: E-GEOD-27081 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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dKDM5/LID regulates H3K4me3 dynamics at the transcription-start site (TSS) of actively transcribed developmental genes.

Lloret-Llinares Marta M   Pérez-Lluch Sílvia S   Rossell David D   Morán Tomás T   Ponsa-Cobas Joan J   Auer Herbert H   Corominas Montserrat M   Azorín Fernando F  

Nucleic acids research 20120816 19

H3K4me3 is a histone modification that accumulates at the transcription-start site (TSS) of active genes and is known to be important for transcription activation. The way in which H3K4me3 is regulated at TSS and the actual molecular basis of its contribution to transcription remain largely unanswered. To address these questions, we have analyzed the contribution of dKDM5/LID, the main H3K4me3 demethylase in Drosophila, to the regulation of the pattern of H3K4me3. ChIP-seq results show that, at  ...[more]

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