Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Meinrad Busslinger
PROVIDER: E-GEOD-27214 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Ebert Anja A McManus Shane S Tagoh Hiromi H Medvedovic Jasna J Salvagiotto Giorgia G Novatchkova Maria M Tamir Ido I Sommer Andreas A Jaritz Markus M Busslinger Meinrad M
Immunity 20110201 2
V(H)-DJ(H) recombination of the immunoglobulin heavy chain (Igh) locus is temporally and spatially controlled during early B cell development, and yet no regulatory elements other than the V(H) gene promoters have been identified throughout the entire V(H) gene cluster. Here, we discovered regulatory sequences that are interspersed in the distal V(H) gene region. These conserved repeat elements were characterized by the presence of Pax5 transcription factor-dependent active chromatin by binding ...[more]