Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Meinrad Busslinger
PROVIDER: E-GEOD-43008 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Medvedovic Jasna J Ebert Anja A Tagoh Hiromi H Tamir Ido M IM Schwickert Tanja A TA Novatchkova Maria M Sun Qiong Q Huis In 't Veld Pim J PJ Guo Chunguang C Yoon Hye Suk HS Denizot Yves Y Holwerda Sjoerd J B SJ de Laat Wouter W Cogné Michel M Shi Yang Y Alt Frederick W FW Busslinger Meinrad M
Immunity 20130801 2
The immunoglobulin heavy-chain (Igh) locus undergoes large-scale contraction in pro-B cells, which facilitates VH-DJH recombination by juxtaposing distal VH genes next to the DJH-rearranged gene segment in the 3' proximal Igh domain. By using high-resolution mapping of long-range interactions, we demonstrate that local interaction domains established the three-dimensional structure of the extended Igh locus in lymphoid progenitors. In pro-B cells, these local domains engaged in long-range intera ...[more]