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Comparative Genomic Hybridization of E. coli and Shigella species to determine the relatedness of isolates from Neobladders

ABSTRACT: Using comparative genomic hybridization we examined the genome content of 30 isolates of E. coli and Shigella to determine the relative location of E. coli isolates from the human neobladder Isolates were included in the study that represent the prototype strains of multiple pathovars. No replicates were included in the final comparisons

ORGANISM(S): Shigella sonnei

SUBMITTER: David Rasko

PROVIDER: E-GEOD-27326 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Genomic characterization of asymptomatic Escherichia coli isolated from the neobladder.

Sahl Jason W JW Lloyd Amanda L AL Redman Julia C JC Cebula Thomas A TA Wood David P DP Mobley Harry L T HLT Rasko David A DA

Microbiology (Reading, England) 20110120 Pt 4

The replacement of the bladder with a neobladder made from ileal tissue is the prescribed treatment in some cases of bladder cancer or trauma. Studies have demonstrated that individuals with an ileal neobladder have recurrent colonization by Escherichia coli and other species that are commonly associated with urinary tract infections; however, pyelonephritis and complicated symptomatic infections with ileal neobladders are relatively rare. This study examines the genomic content of two E. coli i ...[more]

PMID: 21252277

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