Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: John Hawse
PROVIDER: E-GEOD-27375 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Wu Xianglin X Subramaniam Malayannan M Grygo Sarah B SB Sun Zhifu Z Negron Vivian V Lingle Wilma L WL Goetz Matthew P MP Ingle James N JN Spelsberg Thomas C TC Hawse John R JR
Breast cancer research : BCR 20110310 2
<h4>Introduction</h4>We have previously demonstrated that endoxifen is the most important tamoxifen metabolite responsible for eliciting the anti-estrogenic effects of this drug in breast cancer cells expressing estrogen receptor-alpha (ERα). However, the relevance of ERβ in mediating endoxifen action has yet to be explored. Here, we characterize the molecular actions of endoxifen in breast cancer cells expressing ERβ and examine its effectiveness as an anti-estrogenic agent in these cell lines. ...[more]