Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Gordon Brown
PROVIDER: E-MTAB-785 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Zwart Wilbert W Theodorou Vasiliki V Kok Marleen M Canisius Sander S Linn Sabine S Carroll Jason S JS
The EMBO journal 20111014 23
The complexity of oestrogen receptor α (ERα)-mediated transcription is becoming apparent, but global insight into the co-regulatory proteins that assist ERα transcription is incomplete. Here, we present the most comprehensive chromatin-binding landscape of ERα co-regulatory proteins to date. We map by ChIP-seq the essential p160 co-regulators (SRC1, SRC2 and SRC3), and the histone acetyl transferases p300 and CBP in MCF-7 breast cancer cells. We find a complex network of co-regulator binding, wi ...[more]