Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Wayne Hancock
PROVIDER: E-GEOD-27434 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Wang Liqing L Liu Yujie Y Beier Ulf H UH Han Rongxiang R Bhatti Tricia R TR Akimova Tatiana T Hancock Wayne W WW
Blood 20130226 18
Protocols to use Foxp3+ T-regulatory (Treg) cells for cellular therapy, especially postallogeneic stem cell transplantation, are currently being developed and tested by various groups. Inhibitors of DNA methyltransferase (Dnmt) enzymes have been advocated as a means to promote and stabilize Foxp3 expression in Tregs undergoing expansion in vitro before their injection in vivo. We investigated the effects of conditionally deleting two Dnmt enzymes that co-immunoprecipitated with Foxp3 in Treg iso ...[more]