Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Wayne Hancock
PROVIDER: E-GEOD-27896 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
de Zoeten Edwin F EF Wang Liqing L Butler Kyle K Beier Ulf H UH Akimova Tatiana T Sai Hong H Bradner James E JE Mazitschek Ralph R Kozikowski Alan P AP Matthias Patrick P Hancock Wayne W WW
Molecular and cellular biology 20110328 10
Foxp3(+) T-regulatory cells (Tregs) are key to immune homeostasis such that their diminished numbers or function can cause autoimmunity and allograft rejection. Foxp3(+) Tregs express multiple histone/protein deacetylases (HDACs) that regulate chromatin remodeling, gene expression, and protein function. Pan-HDAC inhibitors developed for oncologic applications enhance Treg production and Treg suppression function but have limited nononcologic utility given their broad actions and various side eff ...[more]