Human cerebral cortex DNA methylation by MeDIP-Chip

ABSTRACT: Comparing genetic differences between human and nonhuman primates is a fundamental method to dissect the molecular mechanisms underlying the improved human cognitive ability during evolution. Besides DNA sequence divergences, gene regulation differences between human and nonhuman primates have been shown to be more prominent. DNA methylation is an important type of epigenetic modification that plays critical roles in gene regulations. Trans-generational inheritances of DNA methylation in mammals are widely accepted, suggesting the evolutionary role of DNA methylation. To test if DNA methylation has contributed to the evolution of human brain, with the use of MeDIP-Chip and SEQUENOM MassARRAY, we conducted a systematic analysis to identify the differentially methylated DNA regions (DMRs) be

ORGANISM(S): Homo sapiens

SUBMITTER: Jinkai Wang 

PROVIDER: E-GEOD-27459 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress