Unknown,Transcriptomics,Genomics,Proteomics

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An interspecies analysis reveals sequence determinants of the bivalent chromatin state


ABSTRACT: The sequence determinants of chromatin bivalency remain unclear. We analysed sequence determinants of chromatin bivalency genome-wide in several mammalian species and performed a series of transgenic experiments in mouse ES cells. Genome-wide mapping of H3K27me3 in rat ES cells and ChIP-seq with anti-Ezh2 antibody in transgenic mouse ES cells

ORGANISM(S): Rattus norvegicus

SUBMITTER: Magnus Lynch 

PROVIDER: E-GEOD-27580 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications


The role of DNA sequence in determining chromatin state is incompletely understood. We have previously demonstrated that large chromosomal segments from human cells recapitulate their native chromatin state in mouse cells, but the relative contribution of local sequences versus their genomic context remains unknown. In this study, we compare orthologous chromosomal regions for which the human locus establishes prominent sites of Polycomb complex recruitment in pluripotent stem cells, whereas the  ...[more]

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