Ontology highlight
ABSTRACT:
ORGANISM(S): Rattus norvegicus
SUBMITTER: Magnus Lynch
PROVIDER: E-GEOD-27580 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Lynch Magnus D MD Smith Andrew J H AJ De Gobbi Marco M Flenley Maria M Hughes Jim R JR Vernimmen Douglas D Ayyub Helena H Sharpe Jacqueline A JA Sloane-Stanley Jacqueline A JA Sutherland Linda L Meek Stephen S Burdon Tom T Gibbons Richard J RJ Garrick David D Higgs Douglas R DR
The EMBO journal 20111104 2
The role of DNA sequence in determining chromatin state is incompletely understood. We have previously demonstrated that large chromosomal segments from human cells recapitulate their native chromatin state in mouse cells, but the relative contribution of local sequences versus their genomic context remains unknown. In this study, we compare orthologous chromosomal regions for which the human locus establishes prominent sites of Polycomb complex recruitment in pluripotent stem cells, whereas the ...[more]