Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Christopher Benner
PROVIDER: E-GEOD-60604 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Wu Jun J Okamura Daiji D Li Mo M Suzuki Keiichiro K Luo Chongyuan C Ma Li L He Yupeng Y Li Zhongwei Z Benner Chris C Tamura Isao I Krause Marie N MN Nery Joseph R JR Du Tingting T Zhang Zhuzhu Z Hishida Tomoaki T Takahashi Yuta Y Aizawa Emi E Kim Na Young NY Lajara Jeronimo J Guillen Pedro P Campistol Josep M JM Esteban Concepcion Rodriguez CR Ross Pablo J PJ Saghatelian Alan A Ren Bing B Ecker Joseph R JR Izpisua Belmonte Juan Carlos JC
Nature 20150506 7552
Pluripotency, the ability to generate any cell type of the body, is an evanescent attribute of embryonic cells. Transitory pluripotent cells can be captured at different time points during embryogenesis and maintained as embryonic stem cells or epiblast stem cells in culture. Since ontogenesis is a dynamic process in both space and time, it seems counterintuitive that these two temporal states represent the full spectrum of organismal pluripotency. Here we show that by modulating culture paramet ...[more]