Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Yi Zhang
PROVIDER: E-GEOD-27613 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Wu Hao H D'Alessio Ana C AC Ito Shinsuke S Wang Zhibin Z Cui Kairong K Zhao Keji K Sun Yi Eve YE Zhang Yi Y
Genes & development 20110401 7
Recent studies have demonstrated that the Ten-eleven translocation (Tet) family proteins can enzymatically convert 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC). While 5mC has been studied extensively, little is known about the distribution and function of 5hmC. Here we present a genome-wide profile of 5hmC in mouse embryonic stem (ES) cells. A combined analysis of global 5hmC distribution and gene expression profile in wild-type and Tet1-depleted ES cells suggests that 5hmC is enrich ...[more]