Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: H. Stunnenberg
PROVIDER: E-GEOD-31343 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Matarese Filomena F Carrillo-de Santa Pau Enrique E Stunnenberg Hendrik G HG
Molecular systems biology 20111220
The discovery of the Ten-Eleven-Translocation (TET) oxygenases that catalyze the hydroxylation of 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC) has triggered an avalanche of studies aiming to resolve the role of 5hmC in gene regulation if any. Hitherto, TET1 is reported to bind to CpG-island (CGI) and bivalent promoters in mouse embryonic stem cells, whereas binding at DNAseI hypersensitive sites (HS) had escaped previous analysis. Significant enrichment/accumulation of 5hmC but not 5 ...[more]