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Gene expression profiles of control GC424 tumor cell lines and after downregulation of the SV40 large T-antigen

ABSTRACT: Analysis of global gene expression in a tumor cell line established from a CEA424-Tag mouse and comparison with the expressed gene profile after downregulating the expression of the large T antigen Total RNA obtained from cultured control cell lines and after siRNA mediated downregulation of the SV40 large T antigen

ORGANISM(S): Mus musculus

SUBMITTER: Joachim Schultze

PROVIDER: E-GEOD-27710 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Expression of a neuroendocrine gene signature in gastric tumor cells from CEA 424-SV40 large T antigen-transgenic mice depends on SV40 large T antigen.

Ihler Fritz F Vetter Elena Viviana EV Pan Jie J Kammerer Robert R Debey-Pascher Svenja S Schultze Joachim L JL Zimmermann Wolfgang W Enders Georg G

PloS one 20120113 1

<h4>Background</h4>A large fraction of murine tumors induced by transgenic expression of SV40 large T antigen (SV40 TAg) exhibits a neuroendocrine phenotype. It is unclear whether SV40 TAg induces the neuroendocrine phenotype by preferential transformation of progenitor cells committed to the neuroendocrine lineage or by transcriptional activation of neuroendocrine genes.<h4>Methodology/principal findings</h4>To address this question we analyzed CEA424-SV40 TAg-transgenic mice that develop spont ...[more]

PMID: 22253802

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