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Transcription profiling of mouse cell lines immune sensitive P0 and immune resistant P3 identifies a tumor immune evasion mechanism using P0 and P3 cell lines

ABSTRACT: The emergence of immune resistance variants during immunotherapy is poorly understood. We generated a highly immune resistant cell line (P3) from a susceptible cell line (P0) by subjecting it to 3 rounds of in vivo immune selection. Subsequently, microarray analysis of P0 and P3 was performed to identify genes that may contribute to the increase in immune resistance. Experiment Overall Design: Four experimental replicates were prepared for each cell line. P0 is the control cell line, and P3 is the experimental/resistant cell line.

ORGANISM(S): Mus musculus

SUBMITTER: Ken-Yu Lin 

PROVIDER: E-GEOD-2774 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Ectopic expression of vascular cell adhesion molecule-1 as a new mechanism for tumor immune evasion.

Lin Ken-Yu KY   Lu Dan D   Hung Chien-Fu CF   Peng Shiwen S   Huang Lanqing L   Jie Chunfa C   Murillo Francisco F   Rowley Jesse J   Tsai Ya-Chea YC   He Liangmei L   Kim Dae-Jin DJ   Jaffee Elizabeth E   Pardoll Drew D   Wu T-C TC  

Cancer research 20070201 4

Immune escape is an important reason why the immune system cannot control tumor growth, but how escape variants emerge during immunotherapy remains poorly understood. Here, we identify a new mechanism of tumor immune escape using an in vivo selection strategy. We generated a highly immune-resistant cancer cell line (P3) by subjecting a susceptible cancer cell line (P0/TC-1) to multiple rounds of in vivo immune selection. Microarray analysis of P0 and P3 revealed that vascular cell adhesion molec  ...[more]

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