Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Ken-Yu Lin
PROVIDER: E-GEOD-2774 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Cancer research 20070201 4
Immune escape is an important reason why the immune system cannot control tumor growth, but how escape variants emerge during immunotherapy remains poorly understood. Here, we identify a new mechanism of tumor immune escape using an in vivo selection strategy. We generated a highly immune-resistant cancer cell line (P3) by subjecting a susceptible cancer cell line (P0/TC-1) to multiple rounds of in vivo immune selection. Microarray analysis of P0 and P3 revealed that vascular cell adhesion molec ...[more]