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Gene expression profile of mouse hematopoietic cells

ABSTRACT: Each fraction of mouse hematopoietic cells was purified by cell sorting from bone marrow of 8-week-old C57BL/6 mice, and its gene expression was analyzed. Two biological replicates of each fraction were analyzed using a Mouse Genome 430 2.0 array (Affymetrix).

ORGANISM(S): Mus musculus

SUBMITTER: Hitoshi Ichikawa

PROVIDER: E-GEOD-27786 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Forced expression of the histone demethylase Fbxl10 maintains self-renewing hematopoietic stem cells.

Konuma Takaaki T Nakamura Shunsuke S Miyagi Satoru S Negishi Masamitsu M Chiba Tetsuhiro T Oguro Hideyuki H Yuan Jin J Mochizuki-Kashio Makiko M Ichikawa Hitoshi H Miyoshi Hiroyuki H Vidal Miguel M Iwama Atsushi A

Experimental hematology 20110412 6

<h4>Objective</h4>The methylation status of histones changes dramatically depending on cellular context and defines cell type-specific gene expression profiles. Histone demethylases have recently been implicated in this process. However, it is unknown how histone demethylases function in the maintenance of self-renewing hematopoietic stem cells (HSCs).<h4>Materials and methods</h4>We profiled the expression of histone demethylase genes in mouse hematopoietic cells and listed genes preferentially ...[more]

PMID: 21540074

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