Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Camille Lobry
PROVIDER: E-GEOD-27811 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Nature 20110501 7346
Notch signalling is a central regulator of differentiation in a variety of organisms and tissue types. Its activity is controlled by the multi-subunit γ-secretase (γSE) complex. Although Notch signalling can play both oncogenic and tumour-suppressor roles in solid tumours, in the haematopoietic system it is exclusively oncogenic, notably in T-cell acute lymphoblastic leukaemia, a disease characterized by Notch1-activating mutations. Here we identify novel somatic-inactivating Notch pathway mutat ...[more]