Unknown,Transcriptomics,Genomics,Proteomics

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Expression data of Sham and post-MI myocardium from swine


ABSTRACT: The molecular mechanism underlying cardiac remodeling following myocardial infarction have been incompletely understood. Until now, most studies have been performed in rodents. We studied cardiac remodeling in the physiologically more relevant animal model, the swine. Microarray analysis was performed on animals that underwent either sham surgery or permanent ligation of the left coronary artery (MI). RNA was isolated from the remote, non-ischemic, regions of the left ventricle. RNA was isolated from 8 sham and 8 MI animals three weeks after surgery. Each group contained 4 males and 4 females. Animals used for the study were 2-3 months old Yorkshire x Landrace swine. Only neutered males entered the study.

ORGANISM(S): Sus scrofa

SUBMITTER: Diederik Kuster 

PROVIDER: E-GEOD-27962 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Left ventricular remodeling in swine after myocardial infarction: a transcriptional genomics approach.

Kuster Diederik W D DW   Merkus Daphne D   Kremer Andreas A   van Ijcken Wilfred F J WF   de Beer Vincent J VJ   Verhoeven Adrie J M AJ   Duncker Dirk J DJ  

Basic research in cardiology 20111105 6


Despite the apparent appropriateness of left ventricular (LV) remodeling following myocardial infarction (MI), it poses an independent risk factor for development of heart failure. There is a paucity of studies into the molecular mechanisms of LV remodeling in large animal species. We took an unbiased molecular approach to identify candidate transcription factors (TFs) mediating the genetic reprogramming involved in post-MI LV remodeling in swine. Left ventricular tissue was collected from remot  ...[more]

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