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Transcription profiling of models of cardiac remodelling: myocardial infarction or transverse aortic constriction in left ventricle free wall and septum

ABSTRACT: We employed the Affymetrix GeneChip technology to evaluate the patterns of expression in two different in vivo models of cardiac remodeling and in two different regions (left ventricle free wall and septum) of the heart. Mice underwent transverse aortic constriction (TAC); myocardial infarction (MI) or Sham operation and RNA from the left ventricle free wall and the septum was isolated 1 week later.

ORGANISM(S): Mus musculus

DISEASE(S): normal

SUBMITTER: Maria Mirotsou

PROVIDER: E-GEOD-415 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Elucidating the molecular mechanism of cardiac remodeling using a comparative genomic approach.

Mirotsou Maria M Watanabe Coran M H CM Schultz Peter G PG Pratt Richard E RE Dzau Victor J VJ

Physiological genomics 20031017 2

It is proposed that analysis of global gene expression would provide an understanding of the molecular mechanisms of cardiac remodeling. However, previous studies have only provided "snapshots" of differential gene expression. Furthermore, the differences in gene expression between regions of the heart that can result in sampling variability have not been characterized. In this study, we employed the Affymetrix GeneChip technology to evaluate the patterns of expression in two different in vivo m ...[more]

PMID: 12902547

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Mouse models of cardiac remodeling

Project description:We employed the Affymetrix GeneChip technology to evaluate the patterns of expression in two different in vivo models of cardiac remodeling and in two different regions (left ventricle free wall and septum) of the heart. Mice underwent transverse aortic constriction (TAC); myocardial infarction (MI) or Sham operation and RNA from the left ventricle free wall and the septum was isolated 1 week later. Keywords: other

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