Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Samuel Pena-Llopis
PROVIDER: E-GEOD-27982 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Peña-Llopis Samuel S Vega-Rubin-de-Celis Silvia S Schwartz Jacob C JC Wolff Nicholas C NC Tran Tram Anh T TA Zou Lihua L Xie Xian-Jin XJ Corey David R DR Brugarolas James J
The EMBO journal 20110729 16
Mammalian target of rapamycin (mTOR) complex 1 (mTORC1) is an important, highly conserved, regulator of cell growth. Ancient among the signals that regulate mTORC1 are nutrients. Amino acids direct mTORC1 to the surface of the late endosome/lysosome, where mTORC1 becomes receptive to other inputs. However, the interplay between endosomes and mTORC1 is poorly understood. Here, we report the discovery of a network that links mTORC1 to a critical component of the late endosome/lysosome, the V-ATPas ...[more]