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PPD stimulated PBMCs from tuberculosis patients, latent infectious individuals and healthy controls.

ABSTRACT: Comprehensively compare the transcriptional difference in PPD stimulated PBMCs from individuals with different tuberculosis infectious status: tuberculosis patients, latent infectious individuals and healthy controls using the microarray analysis. Two-condition experiment, PBMCs vs. PPD-PBMCs. 12 individuals: 4 TB patients, 4 latent infectious individuals and 4 healthy controls.

ORGANISM(S): Homo sapiens

SUBMITTER: Chanyi Lu

PROVIDER: E-GEOD-27984 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Novel biomarkers distinguishing active tuberculosis from latent infection identified by gene expression profile of peripheral blood mononuclear cells.

Lu Chanyi C Wu Jing J Wang Honghai H Wang Sen S Diao Ni N Wang Feifei F Gao Yan Y Chen Jiazhen J Shao Lingyun L Weng Xinhua X Zhang Ying Y Zhang Wenhong W

PloS one 20110831 8

<h4>Background</h4>Humans infected with Mycobacterium tuberculosis (MTB) can delete the pathogen or otherwise become latent infection or active disease. However, the factors influencing the pathogen clearance and disease progression from latent infection are poorly understood. This study attempted to use a genome-wide transcriptome approach to identify immune factors associated with MTB infection and novel biomarkers that can distinguish active disease from latent infection.<h4>Methodology/princ ...[more]

PMID: 21904626

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