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Charaterization of the initial molecular events of adipose tissue development and growth during overfeeding in humans

ABSTRACT: The adaptive mechanisms in response to excess energy supply are still poorly known in humans. Our aims were to define metabolic responses and changes in gene expression in adipose tissue of healthy volunteers during fat overfeeding. Healthy lean and overweight subjects were submitted to a high fat diet during 56 days. Adipose tissue biopsies were taken at Day 0, Day 14 and Day 56.

ORGANISM(S): Homo sapiens

SUBMITTER: emmanuelle meugnier

PROVIDER: E-GEOD-28005 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Subcutaneous adipose tissue remodeling during the initial phase of weight gain induced by overfeeding in humans.

Alligier M M Meugnier E E Debard C C Lambert-Porcheron S S Chanseaume E E Sothier M M Loizon E E Hssain A Ait AA Brozek J J Scoazec J-Y JY Morio B B Vidal H H Laville M M

The Journal of clinical endocrinology and metabolism 20111207 2

<h4>Context</h4>Deciphering the early processes occurring in adipose tissue during weight gain is a major issue for understanding the development of fat mass and obesity. Experimental overfeeding in humans is a unique situation to tackle these events.<h4>Objective</h4>Our aim was to identify the pathways involved in sc adipose tissue remodeling during the initial phase of weight gain.<h4>Research design and methods</h4>Forty-four healthy men were involved in an overfeeding protocol with a lipid- ...[more]

PMID: 22162470

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