Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Addie Whitney
PROVIDER: E-GEOD-2803 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Kobayashi Scott D SD Voyich Jovanka M JM Whitney Adeline R AR DeLeo Frank R FR
Journal of leukocyte biology 20051004 6
Polymorphonuclear leukocytes (PMNs or neutrophils) are the most prominent cellular component of the innate immune system in humans and produce an array of potent cytotoxic molecules. It is important that neutrophils undergo constitutive (spontaneous) apoptosis as a mechanism to facilitate normal cell turnover and immune system homeostasis. Conversely, several proinflammatory cytokines, including granulocyte macrophage-colony stimulating factor (GM-CSF), prolong neutrophil survival. The molecular ...[more]