Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: B Kreiswirth
PROVIDER: E-GEOD-16837 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Kobayashi Scott D SD Braughton Kevin R KR Palazzolo-Ballance Amy M AM Kennedy Adam D AD Sampaio Elizabeth E Kristosturyan Ervand E Whitney Adeline R AR Sturdevant Daniel E DE Dorward David W DW Holland Steven M SM Kreiswirth Barry N BN Musser James M JM DeLeo Frank R FR
Journal of innate immunity 20100626 6
Mechanisms underlying the enhanced virulence phenotype of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) are incompletely defined, but presumably include evasion of killing by human polymorphonuclear leukocytes (PMNs or neutrophils). To better understand this phenomenon, we investigated the basis of rapid PMN lysis after phagocytosis of USA300, a prominent CA-MRSA strain. Survival of USA300 clinical isolates after phagocytosis ultimately resulted in neutrophil lysis. ...[more]