Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Hai-Hui Xue
PROVIDER: E-GEOD-21360 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Wirth Thomas C TC Xue Hai-Hui HH Rai Deepa D Sabel Jaime T JT Bair Tom T Harty John T JT Badovinac Vladimir P VP
Immunity 20100708 1
Repetitive antigen stimulation by prime-boost vaccination or pathogen reencounter increases memory CD8(+) T cell numbers, but the impact on memory CD8(+) T cell differentiation is unknown. Here we showed that repetitive antigen stimulations induced accumulation of memory CD8(+) T cells with uniform effector memory characteristics. However, genome-wide microarray analyses revealed that each additional antigen challenge resulted in the differential regulation of several hundred new genes in the en ...[more]