Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Steven McKinney
PROVIDER: E-GEOD-28383 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Prentice Leah M LM d'Anglemont de Tassigny Xavier X McKinney Steven S Ruiz de Algara Teresa T Yap Damian D Turashvili Gulisa G Poon Steven S Sutcliffe Margaret M Allard Pat P Burleigh Angela A Fee John J Huntsman David G DG Colledge William H WH Aparicio Samuel A J SA
BMC genomics 20110428
<h4>Background</h4>Humans and mice with loss of function mutations in GPR54 (KISS1R) or kisspeptin do not progress through puberty, caused by a failure to release GnRH. The transcriptional networks regulated by these proteins in the hypothalamus have yet to be explored by genome-wide methods.<h4>Results</h4>We show here, using 1 million exon mouse arrays (Exon 1.0 Affymetrix) and quantitative polymerase chain reaction (QPCR) validation to analyse microdissected hypothalamic tissue from Gpr54 and ...[more]