Unknown,Transcriptomics,Genomics,Proteomics

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Differential gene expression in stellate sympathetic ganglia after cardiac pressure overload

ABSTRACT: Transcriptom analysis of stellate sympathetic ganglia after 8 weeks of cardiac pressure overload caused by transverse aortic constriction. Comparative transcriptome analysis was determined using the GeneChip Mouse Genome 430 2.0 Array (Affymetrix, Santa Clara, CA, USA). Six microarrays from stellate sympathetic ganglia of mice were performed 8 weeks after transverse aortic constriction or sham operation.

ORGANISM(S): Mus musculus

SUBMITTER: Lutz Hein 

PROVIDER: E-GEOD-18004 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Sympathetic alpha(2)-adrenoceptors prevent cardiac hypertrophy and fibrosis in mice at baseline but not after chronic pressure overload.

Gilsbach Ralf R   Schneider Johanna J   Lother Achim A   Schickinger Stefanie S   Leemhuis Jost J   Hein Lutz L  

Cardiovascular research 20100118 3

<h4>Aims</h4>alpha(2)-Adrenoceptors modulate cardiovascular function by vasoconstriction or dilatation, by central inhibition of sympathetic activity, or by feedback inhibition of norepinephrine release from sympathetic neurons. Despite detailed knowledge about subtype-specific functions of alpha(2)-receptors, the relative contributions of sympathetic vs. non-sympathetic receptors involved in these cardiovascular effects have not been identified. The aim of this study was to define the physiolog  ...[more]

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