Unknown,Transcriptomics,Genomics,Proteomics

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Diverse routes to oral cancer differing in genome instability and risk for cervical node metastasis

ABSTRACT: Clinically evident oral lesions, oral epithelial dysplasia, precede development of oral squamous cell carcinomas (SCC) and are considered to transform to cancer by acquisition of genetic or epigenetic alterations. Here, we show that, +3q24-qter, -8pter-p23.1, +8q12-q24.2 and +20 are early events identifying two pathways to oral cancers that differ in clinical behavior. One or more of these copy number aberrations is present in the major subgroup (3q8pq20 subtype, 75-80% of lesions) that develops with chromosomal instability and risk for metastasis, while they are absent from the smaller and chromosomally stable non-3q8pq20 subgroup (20-25% of lesions) associated with low risk for metastasis. Thus, +3q, -8p, +8q and +20 is a biomarker for oral SCC metastasis. On the other hand, while increased numbers of genomic alterations can be harbingers of progression to cancer, dysplastic lesions lacking copy number changes cannot be considered benign as they are potential precursors to non-3q8pq20 oral SCC. 63 oral SCCs and adjacent regions of normal tissue, 44 oral dysplasias

ORGANISM(S): Homo sapiens

SUBMITTER: Taku Tokuyasu

PROVIDER: E-GEOD-28407 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Two distinct routes to oral cancer differing in genome instability and risk for cervical node metastasis.

Bhattacharya Aditi A Roy Ritu R Snijders Antoine M AM Hamilton Gregory G Paquette Jesse J Tokuyasu Taku T Bengtsson Henrik H Jordan Richard C K RC Olshen Adam B AB Pinkel Daniel D Schmidt Brian L BL Albertson Donna G DG

Clinical cancer research : an official journal of the American Association for Cancer Research 20111108 22

<h4>Purpose</h4>Problems in management of oral cancers or precancers include identification of patients at risk for metastasis, tumor recurrence, and second primary tumors or risk for progression of precancers (dysplasia) to cancer. Thus, the objective of this study was to clarify the role of genomic aberrations in oral cancer progression and metastasis.<h4>Experimental design</h4>The spectrum of copy number alterations in oral dysplasia and squamous cell carcinomas (SCC) was determined by array ...[more]

PMID: 22068658

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Dataset Information

Diverse routes to oral cancer differing in genome instability and risk for cervical node metastasis

Publications

Two distinct routes to oral cancer differing in genome instability and risk for cervical node metastasis.

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