Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0

ArrayCGH mapping of the recurrent 3q26.3-q27 amplifications in lung Squamous Cell Carcinoma (SCC)

ABSTRACT: To prospectively identify new oncogenes implicated in lung Squamous Cell Carcinoma pathogenesis, we investigated chromosome 3 aberrations in advanced tumours using arrayCGH. Chromosome 3 aberrations are indeed among the most frequent alterations in lung SCC and correlate with SCC patient's poor prognosis. We have precisely mapped regions of recurrent losses at 3p and gains at 3q25-qter in a series of lung SCC (GSE14859) amd moreover uncover 3q26.3-q27 high level amplifications in 20% of tumours. These amplicons were precisely mapped in these tumors using arraCGH with a 3q26.3 dedicated tiling array. Keywords : ArrayCGH, lung Squamous Cell Carcinoma, 3q26.3, SOX2 Keywords: ArrayCGH Profiling of 5 advanced (stage III) lung SCC using a chromosome 3 array providing 3q26.3-q27 tiling coverage. Replicates : each array contains three replicates per clone and each sample is hybridized to two arrays, results are subsequently averaged.

ORGANISM(S): Homo sapiens

SUBMITTER: Thomas Hussenet 

PROVIDER: E-GEOD-15079 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

Json Xml
altmetric image

Publications

SOX2 is an oncogene activated by recurrent 3q26.3 amplifications in human lung squamous cell carcinomas.

Hussenet Thomas T   Dali Soraya S   Exinger Julien J   Monga Ben B   Jost Bernard B   Dembelé Doulaye D   Martinet Nadine N   Thibault Christelle C   Huelsken Joerg J   Brambilla Elisabeth E   du Manoir Stanislas S  

PloS one 20100129 1

Squamous cell carcinoma (SCC) of the lung is a frequent and aggressive cancer type. Gene amplifications, a known activating mechanism of oncogenes, target the 3q26-qter region as one of the most frequently gained/amplified genomic sites in SCC of various types. Here, we used array comparative genomic hybridization to delineate the consensus region of 3q26.3 amplifications in lung SCC. Recurrent amplifications occur in 20% of lung SCC (136 tumors in total) and map to a core region of 2 Mb (Megaba  ...[more]

Similar Datasets

Transcriptomics ArrayCGH mapping of chromosome 3 aberrations in lung Squamous Cell Carcinoma (SCC)
2010-05-14 | E-GEOD-14859 | biostudies-arrayexpress
Transcriptomics SOX2 is a new oncogene activated by the recurrent 3q26.3 amplifications in lung Squamous Cell Carcinoma
2010-05-14 | E-GEOD-15080 | biostudies-arrayexpress
Genomics ArrayCGH mapping of the recurrent 3q26.3-q27 amplifications in lung Squamous Cell Carcinoma (SCC)
2010-02-10 | GSE15079 | GEO
Genomics ArrayCGH mapping of chromosome 3 aberrations in lung Squamous Cell Carcinoma (SCC)
2010-02-10 | GSE14859 | GEO
Genomics Homo sapiens
| PRJNA123187 | ENA
Transcriptomics Comparative genomic hybridization of 17 favourable histology Wilms tumour samples taken at immediate nephrectomy in order to identify changes in DNA copy number associated with clinical outcome
2006-05-11 | E-TABM-13 | biostudies-arrayexpress
Transcriptomics Diverse routes to oral cancer differing in genome instability and risk for cervical node metastasis
2011-11-18 | E-GEOD-28407 | biostudies-arrayexpress
Transcriptomics MicroRNA Expression Profile Reveals Important Clinical Tools for the Pathology of Lung Cancer
2010-02-10 | E-GEOD-15008 | biostudies-arrayexpress
Genomics Homo sapiens
| PRJNA123213 | ENA
Transcriptomics Comparative genomic hybridization of 100 favourable histology Wilms tumour samples taken at immediate nephrectomy in order to identify changes in DNA copy number associated with clinical outcome
2006-05-11 | E-TABM-10 | biostudies-arrayexpress