Unknown,Transcriptomics,Genomics,Proteomics

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Gene expression data from teratomas formed by C57BL/6 (B6) ES and EiPS cells in B6 mice


ABSTRACT: Embryonic fibroblast from C57BL/6 (B6) mice were reprogrammed to EiPS without exogenous DNA integration using an single episomal vector. The EiPS cells and B6 ES cells were then transplanted into B6 mice to form teratomas. We used microarrays to profile the gene expression differences between the teratomas formed by B6 ES cells and EiPS cells. Pooled RNA from two teratomas formed by B6 ES or two regression teratomas formed by EiPS were selected for hybridization on Affymetrix microarrays.

ORGANISM(S): Mus musculus

SUBMITTER: Tongbiao Zhao 

PROVIDER: E-GEOD-28573 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Immunogenicity of induced pluripotent stem cells.

Zhao Tongbiao T   Zhang Zhen-Ning ZN   Rong Zhili Z   Xu Yang Y  

Nature 20110513 7350


Induced pluripotent stem cells (iPSCs), reprogrammed from somatic cells with defined factors, hold great promise for regenerative medicine as the renewable source of autologous cells. Whereas it has been generally assumed that these autologous cells should be immune-tolerated by the recipient from whom the iPSCs are derived, their immunogenicity has not been vigorously examined. We show here that, whereas embryonic stem cells (ESCs) derived from inbred C57BL/6 (B6) mice can efficiently form tera  ...[more]

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