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Comparison of B6/D2 Whole Brain Alternative Splicing

ABSTRACT: This dataset consists of whole brain samples from 10 B6 and 12 D2 mice, in order to assess the amount of strain-specific alternative splicing. This design consists of whole brain total RNA samples from 10 B6 and 12 D2 mice

ORGANISM(S): Mus musculus

SUBMITTER: Ted Laderas

PROVIDER: E-GEOD-27282 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Computational detection of alternative exon usage.

Laderas Ted G TG Walter Nicole A R NA Mooney Michael M Vartanian Kristina K Darakjian Priscila P Buck Kari K Harrington Christina A CA Belknap John J Hitzemann Robert R McWeeney Shannon K SK

Frontiers in neuroscience 20110513

<h4>Background</h4>With the advent of the GeneChip Exon Arrays, it is now possible to extract "exon-level" expression estimates, allowing for detection of alternative splicing events, one of the primary mechanisms of transcript diversity. In the context of (1) a complex trait use case and (2) a human cerebellum vs. heart comparison on previously validated data, we present a transcript-based statistical model and validation framework to allow detection of alternative exon usage (AEU) between diff ...[more]

PMID: 21625610

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