Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Torben Redmer
PROVIDER: E-GEOD-28594 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Redmer Torben T Diecke Sebastian S Grigoryan Tamara T Quiroga-Negreira Angel A Birchmeier Walter W Besser Daniel D
EMBO reports 20110701 7
We report new functions of the cell-adhesion molecule E-cadherin in murine pluripotent cells. E-cadherin is highly expressed in mouse embryonic stem cells, and interference with E-cadherin causes differentiation. During cellular reprogramming of mouse fibroblasts by OCT4, SOX2, KLF4 and c-MYC, fully reprogrammed cells were exclusively observed in the E-cadherin-positive cell population and could not be obtained in the absence of E-cadherin. Moreover, reprogrammed cells could be established by vi ...[more]