Adaptive evolution in yeast
Ontology highlight
ABSTRACT:
ORGANISM(S): Saccharomyces cerevisiae
SUBMITTER: T Ferea
PROVIDER: E-GEOD-29 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Systematic changes in gene expression patterns following adaptive evolution in yeast.
Ferea T L TL Botstein D D Brown P O PO Rosenzweig R F RF
Proceedings of the National Academy of Sciences of the United States of America 19990801 17
Culturing a population of Saccharomyces cerevisiae for many generations under conditions to which it is not optimally adapted selects for fitter genetic variants. This simple experimental design provides a tractable model of adaptive evolution under natural selection. Beginning with a clonal, founding population, independently evolved strains were obtained from three independent cultures after continuous aerobic growth in glucose-limited chemostats for more than 250 generations. DNA microarrays ...[more]
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