An extreme human-specific delay in cortical synaptic development
Ontology highlight
ABSTRACT:
ORGANISM(S): Macaca mulatta
SUBMITTER: Xiling Liu
PROVIDER: E-GEOD-29140 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Extension of cortical synaptic development distinguishes humans from chimpanzees and macaques.
Liu Xiling X Somel Mehmet M Tang Lin L Yan Zheng Z Jiang Xi X Guo Song S Yuan Yuan Y He Liu L Oleksiak Anna A Zhang Yan Y Li Na N Hu Yuhui Y Chen Wei W Qiu Zilong Z Pääbo Svante S Khaitovich Philipp P
Genome research 20120202 4
Over the course of ontogenesis, the human brain and human cognitive abilities develop in parallel, resulting in a phenotype strikingly distinct from that of other primates. Here, we used microarrays and RNA-sequencing to examine human-specific gene expression changes taking place during postnatal brain development in the prefrontal cortex and cerebellum of humans, chimpanzees, and rhesus macaques. We show that the most prominent human-specific expression change affects genes associated with syna ...[more]
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