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Genome-wide analysis of gene expression in Non-small Cell Lung Cancer

ABSTRACT: Analysis of NSCLC development at gene expression level. Results shows that obvious activation of cell cycle pathway, and significant repression of cell-cell communication pathways. Illumina HumanHT-12 V4.0 expression beadchip Total RNA obtained from 6 paired NSCLC cancer tissue and the adjacent normal tissue.

ORGANISM(S): Homo sapiens

SUBMITTER: lina ma 

PROVIDER: E-GEOD-29249 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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An integrated analysis of miRNA and mRNA expressions in non-small cell lung cancers.

Ma Lina L   Huang Yanyan Y   Zhu Wangyu W   Zhou Shiquan S   Zhou Jihang J   Zeng Fang F   Liu Xiaoguang X   Zhang Yongkui Y   Yu Jun J  

PloS one 20111027 10

Using DNA microarrays, we generated both mRNA and miRNA expression data from 6 non-small cell lung cancer (NSCLC) tissues and their matching normal control from adjacent tissues to identify potential miRNA markers for diagnostics. We demonstrated that hsa-miR-96 is significantly and consistently up-regulated in all 6 NSCLCs. We validated this result in an independent set of 35 paired tumors and their adjacent normal tissues, as well as their sera that are collected before surgical resection or c  ...[more]

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