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Clear cell sarcoma of the kidney demonstrates an embryonic signature indicative of a primitive nephrogenic origin

ABSTRACT: Gene expression profiling of CCSK in comparison with non-neoplastic foetal and adult kidney Total RNA extracted from 22 frozen CCSKs and 6 adult non-neoplastic kidneys and comercially obtained RNA from 4 foetal kidneys, were hybridized to Illumina humanHT-12 v4.0 Expression BeadChip at the SCIBLU Lund University Sweden (http://www.lth.se/sciblu).

ORGANISM(S): Homo sapiens

SUBMITTER: Jenny Karlsson

PROVIDER: E-GEOD-49972 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Clear cell sarcoma of the kidney demonstrates an embryonic signature indicative of a primitive nephrogenic origin.

Karlsson Jenny J Holmquist Mengelbier Linda L Ciornei Cristina D CD Naranjo Arlene A O'Sullivan Maureen J MJ Gisselsson David D

Genes, chromosomes & cancer 20140201 5

Clear cell sarcoma of the kidney (CCSK) is a tumor affecting children with a median age of 3 years at diagnosis. The cell of origin of CCSK is unknown and data on the molecular changes giving rise to CCSK is scarce. This has hindered the identification of positive diagnostic markers and development of molecularly targeted treatment protocols for CCSK. We have characterized a panel of CCSK to gain information regarding its molecular profile and possible origin. High-resolution genomic analysis wi ...[more]

PMID: 24488803

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