Prostate_5azadC
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Hanna Kim
PROVIDER: E-GEOD-2932 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
The retinoic acid synthesis gene ALDH1a2 is a candidate tumor suppressor in prostate cancer.
Kim Hanna H Lapointe Jacques J Kaygusuz Gulsah G Ong David E DE Li Chunde C van de Rijn Matt M Brooks James D JD Pollack Jonathan R JR
Cancer research 20050901 18
Prostate cancer is the most common cancer among men in the United States, and aberrant DNA methylation is known to be an early molecular event in its development. Here, we have used expression profiling to identify novel hypermethylated genes whose expression is induced by treatment of prostate cancer cell lines with the DNA methyltransferase inhibitor 5-Aza-2'-deoxycytidine (5-aza-dC). Of the 271 genes that were induced by 5-aza-dC treatment, 25 also displayed reduced expression in primary pros ...[more]
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