Gene profile of Myeloid derived Suppressive Cells from the Bone Marrow of Lysosomal Acid Lipase Knock-out Mice
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Hong Du
PROVIDER: E-GEOD-29401 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Gene profile of myeloid-derived suppressive cells from the bone marrow of lysosomal acid lipase knock-out mice.
Yan Cong C Ding Xinchun X Dasgupta Nupur N Wu Lingyan L Du Hong H
PloS one 20120227 2
<h4>Background</h4>Lysosomal acid lipase (LAL) controls development and homeostasis of myeloid lineage cells. Loss of the lysosomal acid lipase (LAL) function leads to expansion of myeloid-derived suppressive cells (MDSCs) that cause myeloproliferative neoplasm.<h4>Methodology/principal findings</h4>Affymetrix GeneChip microarray analysis identified detailed intrinsic defects in Ly6G(+) myeloid lineage cells of LAL knock-out (lal-/-) mice. Ingenuity Pathway Analysis revealed activation of the ma ...[more]
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