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Genotyping of human basal cell carcinomas unveils uniparental disomy as a key domatic event.

ABSTRACT: Affymetrix 10K SNP mapping arrays were used to profile 14 basal cell carcinomas (BCCs) with matched blood DNA samples. Loss of heterozygosity (LOH) and copy number abnormality (CNA) profiles were derived from each tumour-blood pair. Experiment Overall Design: 14 BCC/Blood pairs were used in this study to obtain genome-wide SNP profiles. By comparing tumour and blood DNA, LOH for each SNP could be obtained. Signal intensity for each SNP were used to deternime CNA.

ORGANISM(S): Homo sapiens

SUBMITTER: Dr Muy-Teck Teh

PROVIDER: E-GEOD-2959 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Genomewide single nucleotide polymorphism microarray mapping in basal cell carcinomas unveils uniparental disomy as a key somatic event.

Teh Muy-Teck MT Blaydon Diana D Chaplin Tracy T Foot Nicola J NJ Skoulakis Spyros S Raghavan Manoj M Harwood Catherine A CA Proby Charlotte M CM Philpott Michael P MP Young Bryan D BD Kelsell David P DP

Cancer research 20051001 19

Basal cell carcinoma is the most common human cancer with increasing incidence reported worldwide. Despite the aberrant signaling role of the Hedgehog pathway, little is known about the genetic mechanisms underlying basal cell carcinomas. Towards a better understanding of global genetic events, we have employed the Affymetrix Mapping 10K single nucleotide polymorphism (SNP) microarray technique for "fingerprinting" genomewide allelic imbalance in 14 basal cell carcinoma-blood pair samples. This ...[more]

PMID: 16204023

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