The Time-Series Transcriptomic Responses of THP-1 Cells to W-Beijing M. tuberculosis Strains of different sublineages

ABSTRACT: We report a whole-genome expression profiling of PMA-treated THP-1 human macrophages as a host system, infected by W-Beijing strains of different sublineages or the H37Rv reference strain. Surprisingly, we found that host transcriptional responses were irrespective of inter-sublineage variations. Based on this finding, we further showed that such common host transcriptional responses were probably under the control of a regulatory network involving STATs, IRF-1, IRF-7 and Oct-1 transcriptional factors. We also suggested that these putative regulators might act in a cooperative manner to induce the expression of host-responsive genes, particularly those involved in cytokine-cytokine receptor interactions. THP-1 cells were infected by 11 different sublineages plus one reference strain H37Rv

ORGANISM(S): Homo sapiens

SUBMITTER: Hai Fang 

PROVIDER: E-GEOD-29628 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress