Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Wolfgang Wagner
PROVIDER: E-GEOD-29661 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Koch Carmen M CM Joussen Sylvia S Schellenberg Anne A Lin Qiong Q Zenke Martin M Wagner Wolfgang W
Aging cell 20120119 2
Replicative senescence has fundamental implications on cell morphology, proliferation, and differentiation potential. Here, we describe a simple method to track long-term culture based on continuous DNA-methylation changes at six specific CpG sites. This epigenetic senescence signature can be used as biomarker for various cell types to predict the state of cellular senescence with regard to the number of passages, population doublings, or days of in vitro culture. ...[more]