Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Michael Bocker
PROVIDER: E-MTAB-487 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Bocker Michael T MT Hellwig Isabelle I Breiling Achim A Eckstein Volker V Ho Anthony D AD Lyko Frank F
Blood 20110322 19
DNA methylation plays an important role in the self-renewal of hematopoietic stem cells and in the commitment to the lymphoid or myeloid lineages. Using purified CD34⁺ hematopoietic progenitor cells and differentiated myeloid cell populations from the same human samples, we obtained detailed methylation profiles at distinct stages of hematopoiesis. We identified a defined set of differentiation-related genes that are methylated in CD34⁺ hematopoietic progenitor cells but show pronounced DNA hypo ...[more]