Dataset Information
Expression profile of WT and IKKb(EE)IEC epithelial cells (IEC)
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: monica guma
PROVIDER: E-GEOD-29701 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Constitutive intestinal NF-κB does not trigger destructive inflammation unless accompanied by MAPK activation.
The Journal of experimental medicine 20110808 9
Nuclear factor (NF)-κB, activated by IκB kinase (IKK), is a key regulator of inflammation, innate immunity, and tissue integrity. NF-κB and one of its main activators and transcriptional targets, tumor necrosis factor (TNF), are up-regulated in many inflammatory diseases that are accompanied by tissue destruction. The etiology of many inflammatory diseases is poorly understood, but often depends on genetic factors and environmental triggers that affect NF-κB and related pathways. It is unknown, ...[more]
