Unknown,Transcriptomics,Genomics,Proteomics

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Generation of isogenic pluripotent stem cells differing exclusively at two early onset Parkinson point mutations


ABSTRACT: This SuperSeries is composed of the following subset Series: GSE29772: CNV analysis for Generation of isogenic pluripotent stem cells differing exclusively at two early onset Parkinson point mutations GSE29773: Gene Expression Data for Generation of isogenic pluripotent stem cells differing exclusively at two early onset Parkinson point mutations Refer to individual Series

ORGANISM(S): Homo sapiens

SUBMITTER: Albert Cheng 

PROVIDER: E-GEOD-29774 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications


Patient-specific induced pluripotent stem cells (iPSCs) derived from somatic cells provide a unique tool for the study of human disease, as well as a promising source for cell replacement therapies. One crucial limitation has been the inability to perform experiments under genetically defined conditions. This is particularly relevant for late age onset disorders in which in vitro phenotypes are predicted to be subtle and susceptible to significant effects of genetic background variations. By com  ...[more]

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