Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Albert Cheng
PROVIDER: E-GEOD-29774 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Soldner Frank F Laganière Josée J Cheng Albert W AW Hockemeyer Dirk D Gao Qing Q Alagappan Raaji R Khurana Vikram V Golbe Lawrence I LI Myers Richard H RH Lindquist Susan S Zhang Lei L Guschin Dmitry D Fong Lauren K LK Vu B Joseph BJ Meng Xiangdong X Urnov Fyodor D FD Rebar Edward J EJ Gregory Philip D PD Zhang H Steve HS Jaenisch Rudolf R
Cell 20110714 2
Patient-specific induced pluripotent stem cells (iPSCs) derived from somatic cells provide a unique tool for the study of human disease, as well as a promising source for cell replacement therapies. One crucial limitation has been the inability to perform experiments under genetically defined conditions. This is particularly relevant for late age onset disorders in which in vitro phenotypes are predicted to be subtle and susceptible to significant effects of genetic background variations. By com ...[more]