Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Alex Chang
PROVIDER: E-GEOD-29850 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Chang Alex C Y AC Fu YangXin Y Garside Victoria C VC Niessen Kyle K Chang Linda L Fuller Megan M Setiadi Audi A Smrz Justin J Kyle Alastair A Minchinton Andrew A Marra Marco M Hoodless Pamela A PA Karsan Aly A
Developmental cell 20110801 2
The heart is the most common site of congenital defects, and valvuloseptal defects are the most common of the cardiac anomalies seen in the newborn. The process of endothelial-to-mesenchymal transition (EndMT) in the cardiac cushions is a required step during early valve development, and Notch signaling is required for this process. Here we show that Notch activation induces the transcription of both subunits of the soluble guanylyl cyclase (sGC) heterodimer, GUCY1A3 and GUCY1B3, which form the ...[more]